Practically the same: Xyzal vs. Zyrtec. Xyzal and Zyrtec are remarkably similar to each other. Just take a look at their generic names, levocetirizine andSecond-generation antihistamines (like Zyrtec and Claritin) and third-generation antihistamines (like Xyzal, Allegra and Clarinex) are thought to...